Learn about filmmaking in these great masterclasses from Hollywood heavyweight Paul Thomas Anderson.If you’re not familiar with director Paul Thomas Anderson’s work, then the video essay above for Sight and Sound by Kevin B Lee will walk you through five of his works via his penchant for extensive steadicam shots. For some really helpful stills from the video check out this page on Mentorless.com.You can hear the best of Paul Thomas Anderson’s filmmaking advice in these two commentary track collections from Film School Through Commentaries. Paul Thomas Anderson is a fan of commentary tracks himself, and once said “You can learn more from John Sturges’ audio track on the Bad Day At Black Rock laserdisc, than you can from 20 years of filmschool.”You can check out what he’s talking about in this previous post. Paul Thomas Anderson on The MasterIn another great find from Mentorless.com, John Horn from the LA Times interviews Paul Thomas Anderson about his latest film – The Master, featuring the late great Philip Seymour Hoffman. In this final video The Master‘s editor, production designers and costume designer discuss what it’s like to work with PTA as a director and offer plenty of insights on the collaborative process of filmmaking.If you’re still hungry for more then I would also highly recommend the 90 minute making of documentary from the set of Magnolia, which provides an exceptionally intimate window into Anderson’s directing method and personal journey.
These productions faced perilous circumstances and devastating consequences in an attempt to overcome the odds of a dangerous set.Top image via roarthemovie.comLet’s take a look back at some of the high-risk set locations used in Hollywood productions of the past, and how those involved were affected.Remember: Always make your cast and crew’s safety your main priority. For instance, avoid nuclear test sights.The Viking (1931)Video via Justin OakeyThe production of The Viking (1931) was actually relatively straightforward — until the end of principal photography when the filmmakers went in search of more environmental footage. Joining a seal-hunting expedition, director and producer Varick Frissell took some of his crew onboard a ship packed with ice-shattering explosives.At some point, the explosives were compromised and unexpectedly detonated. Twenty-seven people were killed, including Frissell himself. Evidently, even those who take proper precautions are subject to freak accidents.The Conqueror (1956)Video via Aaron LewisOne of the more controversial occurrences in terms of crew safety, the production of The Conquerer in 1956 ultimately led to the belated death of forty-six crew members due to widespread radiation poisoning. The film was shot near St. George, Utah — shortly downwind of a nuclear testing site. Due to false reassurances from the federal government at the time, the production was permitted over the course of a few weeks, during which time many developed cancer.This fiasco is perhaps most infamous for possibly leading to the death of the classic American movie star, John Wayne. Wayne himself even argued his terminal lung cancer was a result of his smoking habits, but undoubtedly, many of the deaths over the ensuing years were attributable to consistent radiation exposure.L’arche de Noe/Noah’s Ark (1928)Video via Nachthymnen CarcharothSupposedly in an effort to properly follow up 1923’s The Ten Commandments, Darryl F. Zanuck and Michael Curtiz sought to recreate the story of Noah’s Ark. In a stubborn attempt to maximize realism, the production team chose to reenact a life-sized flood across the existing set, using over 600,000 gallons of water.Unfortunately, the immense volume of water overwhelmed the crew and drowned three people. This later led to the implementation of more stunt safety regulations, and spurred accusations of carelessness for the crew’s safety. The tragic occurrence can actually be seen in the movie, which still used the footage in the final cut.Roar (1981)Video via Movieclips Film Festivals & Indie FilmsRoar, a 1981 drama thriller, perhaps embraced realism too wholeheartedly in its production. Portraying a private zoo filled with over 100 wild animals, the film actually used a large number of legitimately dangerous wild animals on set.As a result, over seventy of the cast and crew were severely injured. While no injury proved fatal, some crew members required hundreds of stitches to repair their various wounds, which included bites, maulings, broken bones, scalpings, and even cases of gangrene. Gruesome stories such as this one make modern CGI technology all the more appealing in faking on-screen wildlife.The African Queen (1951)This early-1950s adventure film was shot on location in the Congo and Uganda, Africa. At the time, shooting in Africa was far from common, and potentially due to lack of preparation, the cast and crew were exposed to harsh heat, poor nutrition, and widespread dysentery.Video via Danios12345Director John Huston and lead actor Humphrey Bogart were the only two to avoid illness, having only consumed imported whiskey throughout production instead of the contaminated water that caused the outbreak.With modern visual effects, stricter safety regulations, more versatile transportation, and better available stunt equipment, movie production is fortunately much less treacherous now than it was throughout the 20th century.What production environments have you found the most interesting? Let us know in the comments below. read more
No anthem or colors, but Russians are back at track worlds LATEST STORIES Robbie Herndon. Photo by Tristan Tamayo/ INQUIRER.netAfter failing to lead Wangs Basketball to the playoffs, Robbie Herndon gets a new lease on life, this time as a part of Marinerong Pilipino.The Skippers secured a release for the Fil-Am scorer from the Couriers on Wednesday in time for the quarterfinals, beating the 12 noon deadline for roster changes.ADVERTISEMENT The sixth-seed Marinerong Pilipino will have to deal with a twice-to-win disadvantage in the 2017 PBA D-League Foundation Cup quarterfinals as it faces Tanduay on Thursday.Meanwhile, Cignal HD signed up Jeckster Apinan from the free agent pool to bolster to its fort.The 6-foot-5 forward averaged 2.6 points and 1.9 rebounds in the seven games he played for the now-Kia Picanto this season.The Hawkeyes secured sniper Jonathan Uyloan on a loan from Meralco last Monday.Finishing 8-2 in the eliminations, Cignal has earned an outright semifinals berth as it awaits the victor of the Tanduay-Marinerong Pilipino series.ADVERTISEMENT Ethel Booba on hotel’s clarification that ‘kikiam’ is ‘chicken sausage’: ‘Kung di pa pansinin, baka isipin nila ok lang’ MOST READ PH billiards team upbeat about gold medal chances in SEA Games PLAY LIST 03:07PH billiards team upbeat about gold medal chances in SEA Games02:42PH underwater hockey team aims to make waves in SEA Games01:27Filipino athletes get grand send-off ahead of SEA Games02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City01:07Trump talks impeachment while meeting NCAA athletes02:49World-class track facilities installed at NCC for SEA Games Herndon averaged a league second-best 18.6 points, 7.9 rebounds, and 1.8 assists in his 10 games with Wangs, helping the franchise achieve its best record since joining the developmental ranks.Marinerong Pilipino coach Koy Banal is looking to integrate Herndon to his rising squad, which has won its last five games to advance to the playoffs.FEATURED STORIESSPORTSSEA Games: Biñan football stadium stands out in preparedness, completionSPORTSPrivate companies step in to help SEA Games hostingSPORTSWin or don’t eat: the Philippines’ poverty-driven, world-beating pool stars“We’ll count on him to give us depth and outside shooting,” said the seasoned mentor, as Herndon will pair up with veteran Mark Isip, and upstarts Achie Iñigo, Pao Javelona, and Julian Sargent.Also joining Herndon in the Skippers camp will be big man Jon Gabriel. Lacson: SEA Games fund put in foundation like ‘Napoles case’ View comments Trump strips away truth with hunky topless photo tweet FEU Auditorium’s 70th year celebrated with FEU Theater Guild’s ‘The Dreamweavers’ Robredo should’ve resigned as drug czar after lack of trust issue – Panelo Sports Related Videospowered by AdSparcRead Next DILG, PNP back suspension of classes during SEA Games Church, environmentalists ask DENR to revoke ECC of Quezon province coal plant National Coffee Research Development and Extension Center brews the 2nd National Coffee Education Congress Don’t miss out on the latest news and information. read more
Cricket Australia says Test opener and newly-appointed vice-captain David Warner will miss the team’s two-Test tour of Bangladesh because of a fractured left thumb.Warner sustained the injury while batting at Lord’s in the second one-day international against England on September 5. He won’t require surgery and is hoping to be fit for Australia’s home series against New Zealand in November.Australia plays Bangladesh in a three-day tour match in Fatullah beginning October 3 before Tests in the coastal city of Chittagong from October 9 and in the capital Dhaka beginning October 17.It will be the third Test series between the two countries and the first since Australia’s 2-0 victory in Bangladesh in 2006.
New Delhi, Apr 24 (PTI) On the eve of the the second leg of Budget session of Parliament, Congress today said it will work with like-minded opposition parties and try to put government in the dock on a variety of issues including Uttarkhand developments.Party leaders also indicated that an adjournment motion on the Uttarkhand issue would be brought in the Lok Sabha tomorrow and plans are also afoot to embarass the government in the Rajya Sabha on the matter.”When the Government has to be held to account and to be exposed, that is the duty of the Opposition. Parliament has every right to discuss the Uttarakhand development.”Let us not forget that Article 356 has been abused, the authority of the Government has been abused to topple the popularly-elected Government,” partys deputy leader in the Rajya Sabha Anand Sharma told reporters here.He was dismissing BJPs assertion that the Uttarkhand issue cannot be raised in Parliament as it was subjudice. “I can only sympathize with the BJP leaders and Ministers who have said it, for their bankruptcy on this matter”, he said.Taking a dig at the ruling party, another party leader Kapil Sibal remarked Babri Masjid is a matter which is subjudice for the last 26 years. “How many times, has it been raised in Parliament by the BJP? So when it comes to Babri Masjid, it is not subjudice, when it comes to Uttarakhand, it is subjudice.” PTI SPG VMN read more
Matchday four of the Champions League group stage signifies a step up in hostilities in Europe’s top competition. The initial jostling is over and the cut-throat nature of the competition begins to surface.Arguably this is nowhere more evident than in Group C, where Napoli, Paris Saint-Germain and Liverpool are all vying for two qualification spots.Just two points separate the leading three clubs, and the pressure will be on both the Italians and the French when they meet at the San Paolo on Wednesday. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! After playing out a thrilling 2-2 draw a fortnight ago, both have to go all out for the win in the return game to increase their chances of making the last 16. Game Napoli vs Paris Saint-Germain Date Tuesday, November 6 Time 8:00pm BST / 3pm EST TV Channel, Live Stream & How To Watch In the United States (US), the game can be watched live and on-demand with fuboTV (7-day free trial) .New users can sign up for a free seven-day trial of the live sports streaming service, which can be accessed via iOS, Android, Chromecast, Amazon Fire TV, Roku and Apple TV as well as on a web browser. US TV channel Online stream Univision Deportes fubo TV (7-day free trial) In the United Kingdom (UK), the game can be watched live on BT Sport 3 and livestreamed on BT Sport Live. UK TV channel Online stream BT Sport 3 BT Sport Live Squads & Team News Position Napoli players Goalkeepers Meret, Ospina, Karnezis Defenders Rui, Luperto, Maksimovic, Hysaj, Chiriches, Albiol Midfielders Allan, Callejon, Ruiz, Ounas, Hamsik, Zielinski, Insigne, Koulibaly, Diawara Forwards Malcuit, Verdi, Mertens, Rog, Milik Napoli are without the injured pair of Vlad Chiriches and Amin Younes, but otherwise have a full squad of players to work with.The in-form Dries Mertens will start alongside Lorenzo Insigne in attack.Napoli XI: Ospina; Maksimovic, Albiol, Koulibaly, Mario Rui; Callejon, Allan, Hamsik, Ruiz; Mertens, Insigne. Position PSG squad Goalkeepers Buffon, Areola, Cibois Defenders Marquinhos, Thiago Silva, Kehrer, Bernat, Kimpembe, Nsoki, Meunier Midfielders Verratti, Draxler, Di Maria, Diarra, Nkunku, Rabiot Forwards Mbappe, Cavani, Neymar, Choupo-Moting, Diaby Paris Saint-Germain are still without full-backs Layvin Kurzawa and Dani Alves, both of whom have been missing for many weeks now.Julian Draxler gets the nod ahead of Adrien Rabiot in the centre of the park, while Edinson Cavani only makes the bench against his former side after missing the previous two matches with injury. Gianluigi Buffon will make his return to the Champions League arena after serving a three-match ban for a red card against Real Madrid while playing with Juventus last season.PSG starting XI: Buffon; Marquinhos, Thiago Silva, Kehrer; Meunier, Verratti, Draxler, Bernat; Neymar, Mbappe, Di Maria.Betting & Match Odds PSG are 11/10 favourites to take the victory, according to bet 365 , while a draw is available at 27/10. Napoli, meanwhile, are priced at 19/10.Click here to see all of bet 365’s offers for the game, including goalscoring markets, correct score predictions and more. Match Preview Having had things all their own way in Ligue 1 this season, winning all 12 games to set a new European record for victories at the start of the campaign , Paris Saint-Germain must prove in this encounter that they are more than just flat-track bullies and genuine Champions League contenders.So far in the competition, they have barely looked like a team capable of winning it. Red Star Belgrade might have been blown away 6-1 at Parc des Princes , but PSG were well beaten by Liverpool at Anfield on the opening night of action and required a last-gasp Angel Di Maria equaliser to secure a share of the spoils between these sides last time out.Buffon, whose career goal is to win the Champions League, well appreciates the challenge facing his side.“It’s not a normal match. We know it would be very important to win and something big,” he said. “But it’s also important not to lose on Tuesday. We’ll also have the opportunity to win against Liverpool and Red Star.“I know this stadium very well. I think it’s very difficult to win here because the atmosphere is white hot, a tough atmosphere. The team and the supporters share a great feeling. It’s very important to go out to try and win the game, but it’ll be tough. Napoli, as they showed in the first game, is a team to respect.”Indeed, Carlo Ancelotti’s men have already unseated last season’s finalists Liverpool 1-0 at home and can feel aggrieved that they do not already have one foot in the last 16 having come so close against PSG last time out. They lie third in Serie A, having scored 24 times in 11 matches, including five at the weekend against Empoli, so confidence will be high in their ranks that they can take a huge step towards the knockout rounds. read more
The Indian cricket team reached Dublin for a two-match T20I series against Ireland. The matches will be played on June 27 and 29 before Virat Kohli & Co. return to England for a three-match T20I series, a three-match ODI series and a five-match Test series.India had flown out to England over the weekend and got involved in an intense training session. The likes of MS Dhoni, Suresh Raina, KL Rahul and Kohli looked good and sharp at the nets.India are in Ireland after 11 years. Back in 2007, they had played a one-off ODI in Belfast – the match also happened to be Rohit Sharma’s debut even though he did not get to bat.India are placed third in the team rankings with 123 points, while the leader of squad has so far accumulated 670 points with his batting exploits.Hello Dublin ??#TeamIndia #IREvIND pic.twitter.com/GA8kDzsmWcBCCI (@BCCI) June 26, 2018India have the potential of reaching 127 points by winning their five matches – two against Ireland and three against England. On the other hand, England could go up to 126 points if they beat Australia and then defeat India 3-0.TrainingAn intense training session for #TeamIndia ahead of the two T20Is against Ireland.#IREvIND pic.twitter.com/sRqE0F1P26BCCI (@BCCI) June 26, 2018India or England could reach the top spot if Zimbabwe are able to pull off a couple of upsets in the Tri-Series and depending on other results, Australia and Pakistan could be restricted to below those numbers.advertisementIreland and India have played only one T20I before, in the 2009 World T20. India had won by 15 runs. read more
Virat Kohli gave Joe Root a special send-off on Wednesday as he ran the England skipper out with some sensational fielding.The incident took place in the 63rd over of the Day 1 of the first Test between India and England at Edgbaston. Root, who was batting on 80, was sent back to the pavilion as he tried to take a second run with Jonny Bairstow.Kohli, who was mid-wicket, quickly collected the ball and released it swiftly to the non-striker’s end for a direct hit to dismiss Root.The India captain then celebrated the dismissal with a ‘mic drop’ gesture. It was in response to Root’s celebration after he guided England to a 2-1 ODI series win against India in July.Kohli Celebrating the Run Out of Joe Root … pic.twitter.com/g7Alqo4W72Taimoor Zaman (@taimoorze) August 1, 2018With ODI series levelled at 1-1, Root slammed 100 not out at Headingley as England defeated India by eight wickets to clinch the series.Root celebrated the win by dropping his bat with Kohli watching on. The celebration was seen as a statement made by Root prior to the Test series against India.Joe Root hits a four, to score a century, and win the series. One way to celebrate. pic.twitter.com/Ulb4AjxQEDSimonNRicketts (@SimonNRicketts) July 17, 2018Root, however, described his celebration as the most embarrassing thing he had done on a cricket field.”It was something that I immediately regretted,” Root said.”I’ve not heard the end of it, it was literally the most embarrassing thing I’ve done on a cricket field. I don’t think it will be the last I hear of it from the group – they’ve been hammering me.advertisement”You’d think if you were going to do a celebration like that, you’d have smacked it 30 yards out of the ground. It was just an absolute car crash.” read more
4th Test, Day 4, brief scores: India 622 for 7 declared (Pujara 193, Pant 159 not out, Jadeja 81, Lyon 4 for 178) vs Australia (300 all out; Harris 79, Kuldeep 5 for 99) & 6/0 (Harris 2*, Khawaja 4*) at stumps, trail by 316 runs following on. Full ScorecardThe weather in Sydney continued to play spoilsport as play had to be called off early on Day 4 after Australia were asked to follow-on in the second innings by India in the fourth Test on Sunday. The hosts were 6 for no loss when umpires decided to take the players off the field due to bad light.Rain followed soon after tea as the players continued to stay off the field after which the umpires decided enough was enough and called off the day’s play.Australia were forced to follow-on on home soil for the first time in 30 years after being dismissed for 300 as India went for the jugular in search of a maiden series triumph Down Under on the fourth day.Openers Usman Khawaja (4) and Marcus Harris (2) safely negotiated four overs until bad light and light drizzle forced an early end to an already heavily rain-disrupted day just before the re-scheduled tea break.Australia will resume on six without loss on Monday, still without a century in the series and 316 runs adrift of India’s mammoth first innings effort of 622-7 declared.The tourists, leading 2-1 in the four-Test series, only need a draw to secure a breakthrough triumph in Australia but skipper Virat Kohli did not hesitate to send the hosts back in when they fell well short of the 423 runs needed to avoid the follow-on.advertisementPlay at the Sydney Cricket Ground had finally got underway after a rain delay of almost four hours and India needed just 80 minutes to take the last four wickets at a cost of 64 runs.Mohammed Shami immediately took the second new ball and removed Pat Cummins’s off stump with the sixth delivery of the day to dismiss his fellow paceman for 25.Peter Handscomb, recalled for his ability to play spin, followed for 37 after adding nine runs to his overnight tally, dragging the ball onto his stumps to give quick Jasprit Bumrah his first wicket of the match.Nathan Lyon faced just five balls before he was adjudged lbw to fellow spinner Kuldeep Yadav for a duck, a decision Australia decided against reviewing despite a question mark over whether the ball would have hit the stumps.Josh Hazlewood was dropped by Hanuma Vihari off Kuldeep’s bowling when he had yet to score and he and fellow tailender Mitchell Starc (29 not out) fought a dogged rearguard to put on 42 for the final wicket.Left-arm wrist spinner Kuldeep (5-99) finally got his man to secure a second five-wicket haul in his sixth Test, though, trapping Hazlewood leg before wicket for 21, in a decision confirmed after a review.England were the last team to force Australia to follow-on at home in the drawn 1988 Sydney Test, a result the hosts are unlikely to repeat unless the weather intervenes decisively.Also Read | Virat Kohli wasn’t even born when India last enforced follow-on in Australia 33 years agoAlso Read | Kuldeep Yadav 1st Chinaman bowler to bag 5-wicket haul in Tests in Australia in 64 yearsAlso Read | It has been a pleasure working with you my friend: Shane Warne after Kuldeep 5-wicket haul read more
Premier John Hamm and Tourism and Culture Minister RodneyMacDonald offered congratulations today, Sept. 17, to 20-year-oldGary Beals on behalf of all Nova Scotians. Mr. Beals, from Cherry Brook, was the runner up in the finalround of the Canadian Idol contest, a popular TV show aired onCTV. Ryan Malcolm of Kingston, Ont. received more votes than Mr.Beals and was awarded the title Tuesday night. “All Nova Scotians are tremendously proud of Gary,” said PremierHamm. “Not only is he a model of talent and dedication for otheryoung artists, he has created a legacy in his community andthroughout Nova Scotia that will be tough to match. I have nodoubt that he will go on to achieve great things with his music.We are so very proud of him.” “Gary has been a superb ambassador for Nova Scotia and hascarried himself extremely well during this long, arduouscompetition,” said Mr. MacDonald. “Without a doubt, he hasdistinguished himself in a province that has an establishedtradition of great music and talent.” Gary Beals made it to the final round of the contest, whichstarted last spring with 15,000 amateur singers from acrossCanada trying to become a star. read more
New Delhi: A Delhi court has put on trial BJP MLA Manjinder Singh Sirsa and others in a criminal defamation case filed by Delhi minister Satyendar Jain. Additional Chief Metropolitan Magistrate Samar Vishal framed the notice under Section 251 of the CrPC (dealing with issuance of summons in such complaints) against Sirsa and others and fixed the matter for recording of evidence of Jain and his witnesses on July 17. “The accusation under section 251 CrPC has been explained to counsel for accused Manjinder Singh Sirsa as well as to accused Vishnu Prakash Tripathi and Neetendra Srivastava to which they pleaded not guilty and claimed trial. Put up for post notice complainant’s evidence on July 17,” the judge said. Also Read – Bangla Sahib Gurudwara bans use of all types of plastic items Sirsa has alleged that he was indulging in circulating huge amounts of illegitimate money within the party, Jain claimed. He has also accused a media house for publishing the alleged “libellous and slanderous statements” made by Sirsa. His counsel had said that these allegations were made in front of the national media but only one newspaper published it which shows they were hand in glove with each other. Jain had filed two criminal defamation complaints against rebel AAP MLA Kapil Mishra and BJP leader Sirsa for allegedly defaming him by levelling graft charges against him. If convicted, the offence of defamation entails a maximum punishment of two years. Regarding Sirsa, Jain said that, the MLA made libellous statements by levelling corruption allegation against him. He said that making a statement on the basis of “hearsay” without any proof or evidence supporting it, is not only unbecoming of an MLA, but also a crime of defaming a person. read more
New Delhi: E-commerce companies are betting big on small towns to explore the opportunities offered by a large customer base and are expanding their talent pool in these cities to fuel growth, experts say. They expect recruitment to go up by 15 per cent in this space. Small towns are becoming the driving force behind e-commerce growth in the country as online retailers are targeting last mile connectivity and are increasingly focusing on getting the small-town Indian customer to shop online. Also Read – Thermal coal import may surpass 200 MT this fiscalExperts said in order to deal with the rising demands of consumers, e-commerce companies have been setting up warehouses in small towns and have also been expanding their talent base in these towns. The sectors that are expected to grow include logistics, e-wallets, FMCG, and retail as these industries have been focusing on tier II and tier III cities growth and have seen customer base grow faster in comparison to metro cities. “Last year Diwali festive sales showed 40 per cent contribution from tier II and III cities. This is a remarkable change and an indication of the reach of e-commerce. Companies are focusing on warehouse, logistics and last mile connectivity. The job market is growing in these cities and will see a growth of 15 per cent in these cities,” Teamlease Services Head of Digital & IT Mayur Saraswat said. Also Read – Food grain output seen at 140.57 mt in current fiscal on monsoon boostWith competition in metro cities reaching saturation, companies have to look for new markets and hence chasing organic growth in these small towns is a natural option, Saraswat noted. Indeed India Managing Director Sashi Kumar said that as per Indeed data, some of the country’s leading unicorns are seeking talent in tier II and tier III locations. “Haryana sees over 18 per cent of job postings from these companies, as does Uttar Pradesh with 8 per cent of all such job postings. Gujarat (2 per cent) and Rajasthan (2 per cent) also see job postings from these companies,” he said. Some of the job roles that are being posted by these companies include ‘delivery person’, ‘guest service agent’, ‘sales manager’, and ‘field executive’, among others. Kunal Sen, India Managing Director, Korn Ferry RPO and Professional Search noted that “it (hiring in small towns) would be around 30 per cent of the overall hiring share but growing faster than the larger towns”. Experts believe that small cities are future centres of retail growth in the country as there is availability of land at cheaper rates, lower rentals and customers are ready to experiment with new format stores. read more
VILLE-MARIE, Qc – Police say a companion of a 54-year-old man who died while on a hunting trip in northwestern Quebec could be facing charges in the death.Provincial police say the suspect could be charged as of Monday with charges of criminal negligence causing death, careless use of a firearm and discharging a firearm.Police do not have many details about what happened but say they received a call at 1:30 Saturday morning.They met with one of the deceased’s hunting companions and determined that person to be a suspect.Spokeswoman Helene Nepton did not know how many people were on the trip.The death occurred in Bearn, about 650 kilometres northwest of Montreal.
AddThis Sharing ButtonsShare to TwitterTwitterShare to FacebookFacebookShare to RedditRedditShare to 電子郵件Email TOKYO – Japan’s economy grew by a stronger-than-expected 3.5 per cent in annual terms last quarter, giving Prime Minister Shinzo Abe a boost as his government tackles reforms needed to ensure a sustained recovery from two decades of malaise.Stronger consumer spending and public works investment coupled with aggressive monetary easing lent oomph to the recovery that began in the last quarter of 2012, when annual growth was 0.3 per cent.The preliminary data for January to March showed the world’s third-largest economy grew 0.9 per cent on a quarterly basis, the fastest pace in a year, according to figures reported by the Cabinet Office on Thursday.Abe took office in late December after voters fed up with years of economic misery returned his Liberal Democratic Party to power. His policies have helped push share prices to their highest levels in over five years, fueled by strong liquidity and expectations of improved profitability for listed companies.But the real test will be whether the gains can be sustained in the longer run, said Masamichi Adachi, an economist with JP Morgan in Tokyo.“It’s not what we can see from just one quarter’s growth,” he said.Demand has been “front-loaded” by a sharp increase in public works contracts and by household purchases being made now to beat sales tax increases in 2014 and 2015. Keeping growth at the 3 per cent or 4 per cent pace needed to counter deflation and tax hikes expected next year is a “mission impossible,” Adachi said. “The sustainability beyond next year, we just don’t know.”The benchmark Nikkei 225 stock index slipped 0.4 per cent Thursday to close at 15,037.24, falling back on profit taking. But it has gained nearly 75 per cent since November in a rally linked to high hopes for Abe’s policies.“Japan’s healthy-looking GDP data are the first substantial piece of good economic news under the Abe government,” said Julian Jessop, an economist with Capital Economics in London.He said it was unclear how much of the rebound could be attributed to Abe’s policy blend, dubbed “Abenomics,” but that “the government can at least claim some credit for boosting confidence in the economy.”The improvement makes it more likely the government will be able push ahead with its pledges to raise sales taxes over the next two years to help improve Japan’s deteriorating fiscal health, said economy minister Akira Amari.Japan’s public debt is more than twice the size of the economy and still growing as the government struggles to revamp aging infrastructure, rebuild from the March 2011 tsunami and meet the social welfare needs of its increasingly elderly and shrinking population.However, top government spokesman, Yoshihide Suga, said the decision on raising taxes would hinge on how the economy performs over the coming months.“Consumer sentiment seems to have recovered,” Suga told reporters. “But at this point we should not be overly optimistic.”“The Abe administration’s policies are starting to see some results, but we need to achieve economic growth with employment and we will work to achieve this.”Apart from soaring share prices, Japan’s manufacturing and employment showed slight improvements in March, buttressing hopes that the economy may be headed for a moderate recovery. The government on Thursday raised its estimate for industrial production in March, saying it rose 0.9 per cent rather than the earlier-reported 0.2 per cent.A sharp decline in the value of the Japanese yen, brought on by monetary easing and by expectations of further easing, has helped some exporters and provided a windfall in yen terms for companies repatriating overseas earnings. But it is also raising costs for many companies that depend heavily on imports of natural gas and other commodities.Exports rose 3.8 per cent in the first quarter, the first such increase in a year, while consumer spending, which accounts for a hefty 60 per cent of total business activity in Japan, climbed 0.9 per cent as households bought more cars and other durable goods.The central bank, which is committed to 2 per cent inflation within two years, says it expects a moderate recovery by midyear but has warned that uncertainties in the domestic and global economies could foil those hopes.Abe needs fast results as ammunition in an election for the upper house of parliament in July, a vote that will determine his Liberal Democratic Party’s chances for pushing through with other policy priorities, such as revision of Japan’s war-renouncing constitution.Critics of the Abenomics strategy question whether the extra funding pumped into the economy will foster sustainable growth or just push up prices for shares and other assets.Key to the success of the policies will be increased spending by households and corporations, partly due to expectations that prices will rise. So far, increases in spending have been attributed mainly to luxury purchases by share investors splashing out after seeing gains in their portfolios.The first quarter data showed no pickup in corporate investment or in prices.Analysts had generally forecast a 2.7 per cent to 2.8 per cent increase in GDP in January-March and quarterly growth of about 0.7 per cent.Much of the growth in the first quarter of the year came from public demand: government spending on reconstruction from Japan’s March 2011 tsunami disaster and other public works. Private demand has been fueled by a recovery in housing investment, which has picked up sharply as purchasers rush to beat the expected increases in sales taxes.The sales tax increase, while needed to help reduce Japan’s massive public debt, will amount to a “major fiscal tightening,” said Jessop.To keep growth on track, the government will have to carry out fiscal and structural reforms — such as changes in labour, education and tax policies and administrative deregulation — to help improve Japan’s long-term competitiveness and adapt to its aging and shrinking population.In the near term, if companies do not boost wages to help improve household purchasing power, inflationary policies could just discourage consumer spending.Data released Wednesday showed consumer confidence fell slightly in April, though it has improved since late last year. by Elaine Kurtenbach, The Associated Press Posted May 16, 2013 5:44 am MDT Japan sees results from ‘Abenomics’ growth strategy, as GDP jumps 3.5 pct, beating forecasts read more
Mags Mullarney is founder of Move4Parkinson’s. Further information on their ‘five elements’ self-management programme can be found on www.move4parkinsons.com. On Sunday29th of September a group from Move4Parkinson’s will travel to the World Parkinson’s Congress in Montreal, their progress at the conference can be followed via their blog on their website.Facebook: facebook.com/move4parkinsons IN LESS THAN four months I will mark a milestone event, it will be ten years since my diagnosis with Parkinson’s at the age of 47. Since then, there have been good days and there have been bad days, without a doubt though it has taken me on a journey I could never have expected, from completing my first ever marathon, to setting up a charity and establishing a choir for people with Parkinson’s their family members and friends – one which has released its first single and at the end of this week will travel to Montreal to both perform at and attend the World Parkinson’s Congress.It might seem that, like buses, you wait ten years for a story on Parkinson’s to come, and then three come at once. First was the news that Linda Ronstadt had stopped singing following a diagnosis of Parkinson’s, then the news that Billy Connolly has been diagnosed with early stage Parkinson’s, and just last week my good friend Shay Healy shared his personal Parkinson’s story, in his own searingly honest, at time humorous, at times challenging way, on TV3’s Midweek.Each of them is on their own unique journey with this often misunderstood illness, the second most common neurological condition after Alzheimer’s.My story though isn’t just about Parkinson’s, it is about our relationship with medicine and doctors in Ireland, it is about a new paradigm of healthcare that is needed for all chronic illness, one which is patient-led and holistic.We can’t continue doing things the old wayWe all know that our healthcare system is under-resourced and over stretched, we have one of the lowest ratios of neurologists to patients in all of Europe, but I don’t believe that the answer is to put more money into doing things in the same way that we always have.The truth is that we have a relationship with our healthcare professionals that doesn’t work. As patients we need to take more responsibility and ownership for our illnesses. Rather than just take our tablets and wait for our next appointment, it is vital that we understand what we are taking, why we are taking it, how it should work.We also need to look beyond medication; at exercise, nutrition, our mental well-being and other treatments which can form an effective arsenal in our battle against whatever illness it is that we happen to have.We are the ones who understand our illness better than any doctor might, we understand best how we, as unique individuals, are experiencing the illness we have. This is because we are living with our illnesses every day. If we pay attention, we will begin to really understand; how medicines make us feel when we take them in different ways, or at different times; which exercises support our well-being; or how our mental health is being affected by managing a chronic illness every day.Self management is not about ignoring expert adviceThis patient-led approach to healthcare is commonly known as ‘self-management’. It’s not about patients deciding alone what medications or other treatments will work for them, it’s about putting patients at the heart of their treatment. It’s about better communication between patients and healthcare providers and a multi-disciplinary approach that sees our professionals communicating with each-other; neurologists, GPs, physiotherapists, speech therapist and others, all working together with the patient to determine the best course of action.It might sound like a sensible approach, but we shouldn’t underestimate how far we currently are from that model and how much work it will take to change the culture and ways of working needed to get there.A first step, is for us as patients to educate ourselves. According to the WHO, among patients with chronic illness, approximately 50 per cent of us do not take medications as prescribed. This poor adherence to medication leads to increased morbidity and death and is estimated to incur costs of approximately $100 billion per year. It is vital that we take responsibility for learning how to manage our illnesses and take our medication.The comfort of a communityThis is where organisations such as Move4Parkinson’s come in. When I was diagnosed I had nowhere to turn, I was told not to research online because it would scare me, but even without doing it I was terrified, so I figured I had nothing to lose. What I found online was an amazing community of other people with Parkinson’s and specialists around the world.They were also realising that traditional approaches didn’t work, that regular exercise was hugely important for Parkinson’s, that changes as simple as taking medication with a glass of water would make it work better than just dry swallowing tablets.With Move4Parkinson’s we are working to make that information accessible in one place, in a simple way, that is easy to understand. We are working to educate people with Parkinson’s on how to manage their illnesses and how to work with their neurologists and health care workers to achieve the best possible quality of life. The 12,000 people with Parkinson’s living in Ireland deserve that at least.Uploaded by Move4ParkinsonsFeel in control againAs patients, regardless of what illness we have, we have to take ownership for our illnesses, empower ourselves, feel in control of our lives once again. As patient organisations, we can support those with chronic illnesses by teaching them self-management skills. A 2007 study showed that patients with high levels of engagement and active participation in their own care are ten times more likely to report high patient-satisfaction scores, five times more likely to report high quality-of-life scores and report significantly higher physical and mental functional status scores.We need to make self-management more accessible and to come up with more creative and (dare I say it) enjoyable ways, of managing chronic illness. This was one of the drivers for setting up our Move4Parkinson’s choir. It provides not just a sense of community but also supports the speech therapy needs of those with Parkinson’s, to improve and strengthen their vocal power.I believe that it is possible for the Irish healthcare system to move towards this model. This approach works, it has been proven in countries such as The Netherlands, with their ParkinsonsNet initiative, but we need everyone in our health care systems, including us patients, to get behind it in order for it to become a reality. read more
A guide wipes off snows outside the space museum located in Saint Paraskeva church in Pereyaslav-Khemlnytsky, a small town some 80 kilometers southeast of Kiev on 11 January 2019. Photo: AFPInside a traditional Orthodox church topped with a gold cross, instead of icons, visitors can see a lunar rover and the helmet of the first man in space Yuri Gagarin.The wooden church in central Ukraine is one of thousands of buildings that were repurposed or simply destroyed during an anti-religion campaign in the Soviet era.But now some believers are asking whether it’s time for the blue and grey painted structure to be returned to the Church, especially as Ukraine is undergoing a religious revival.Last month the country created its own Orthodox Church in a historic break with the Russian Orthodox Church, against a backdrop of its ongoing war with Russia-backed rebels in eastern Ukraine that has killed more than 10,000 people.”Today, when it is no longer forbidden to pray and believe in God, the church must be used as a place of worship,” said priest Mykhaylo Yurchenko, from the new Ukrainian Orthodox Church who serves in one of the nearby churches.Museum staff say clerics have visited and even tried out the acoustics, but there are no plans to reconsecrate it.”The museum was founded in the 1970s,” said Sergiy Volkodav, its 37-year-old chief curator.”It happened when space flights were wildly popular and every boy dreamed of becoming a cosmonaut,” he said, standing beside a spacesuit worn by cosmonaut Vyacheslav Zudov for a spacewalk in 1976.A guide waits for visitors at the space museum located in Saint Paraskeva church in Pereyaslav-Khemlnytsky, a small town some 80 kilometers southeast of Kiev on 11 January 2019. Photo: AFPBuilt in 1891, the Church of Saint Paraskeva houses over 450 exhibits, including a scarlet training parachute belonging to Gagarin, a collection of portraits of him and other personal items of the cosmonaut whose historic 1961 space flight made him a Soviet icon.The museum is part of a vast outdoor ethnographic complex, located in Pereyaslav-Khmelnytsky, a small town some 80 kilometres (50 miles) southeast of Kiev.’As cold as in space’ Soviet anti-religious propaganda used images of space exploration to persuade people that God did not exist.The Soviets also put some former churches to ideological use such as opening a museum of atheism in a cathedral in Leningrad, now Saint Petersburg.Some other churches were converted into planetariums.Volkodav said that, in opening a space museum in a church, the Soviet authorities’ intention was not necessarily to mock religion.They simply chose a building that could display large exhibits that include a model rocket several metres (feet) high, he said.Some, like Volkodav as well as priests and other locals, argue that the creation of the museum in fact saved the church from destruction.It formerly stood in a Cossack village that was deliberately flooded to build a vast reservoir in the 1960s.The church was one of the few buildings to be painstakingly dismantled and moved to a new location.One of those who lived in the village, Borys Stolyarenko, a 60-year-old mechanic, recalls services being held there in the early 1960s.”Later, when the Soviets turned it into a granary, we climbed through its windows with my friends and jumped down into the grain,” he said.He has no photographs of his former home village, he went on.”All I have is this church. The creation of the museum saved it,” he added.A guide waits for visitors at the space museum located in Saint Paraskeva church in Pereyaslav-Khemlnytsky, a small town some 80 kilometers southeast of Kiev on 11 January 2019. Photo: AFPToday though, the museum looks like it has seen better days. The exhibits are shabby and blue paint is flaking off the interior walls.Most visitors come in summer due to the lack of heating: a thermometer inside displays minus 10 degrees C (14 degrees F).”It’s as cold as in space,” joked a museum employee, wearing a sheepskin coat and hat.Use for worshipThe fall of the USSR and the proclamation of Ukraine’s independence in 1991, followed by religious freedom in this predominantly Orthodox country have not changed the museum’s status.Father Feodosiy from the local Orthodox monastery, loyal to the Moscow Patriarchate, said he would like to see the museum return to the Russian Orthodox Church.But if it were to go to the new Ukrainian Church, he would rather see it continue to host space exhibits, he said.”In the situation we have now, it’s better to have a museum there than those schismatics” from the independent Church, he said.Some locals have suggested moving the space exhibition to another location and opening a museum of religious icons in its place.But Volkodav is resolutely opposed.”This is the only space museum in a church in the whole world… it’s unique,” he claimed. read more
Roku plans to launch a marketplace for video subscription services in the coming months, which will allow consumers to sign up for and watch subscription services without the need to download separate apps on Roku devices, Variety has learned from multiple sources familiar with the company’s plans. The marketplace is said to be similar to Amazon Channels, a popular à la carte offering available on Fire TV devices.A Roku spokesperson declined to comment.Roku has long offered access to subscription services like HBO Now and CBS All Access via its channel store. Consumers who want to access any of these services need to download a dedicated app, also called channel in Roku’s vernacular, onto their streaming device, and then sign up for the service either through their TV or through the service provider’s website. In the future, Roku plans to bring together a number of these paid services in the same channel, making it easier to subscribe to, and then access any premium content, without the need to download and launch different apps. The company has also been working on the next generation of its billing platform, dubbed Roku Pay, to make it easier for consumers to pay for these services.This approach closely mimics Amazon Channels, a subscription video marketplace launched by the e-commerce giant in late 2015. Offered exclusively to Prime members, Amazon Channels offers consumers the ability to easily sign up for over 235 video subscription services directly from their Fire TV device. Once a consumer signs up for any of these paid channels, its content is not presented in a separate app, but right next to Amazon’s Prime Video catalog.The simplicity of Channels has led to Amazon becoming a major force in the à la carte subscription business: The Diffusion Group estimated recently that Amazon is selling more than 50% of all online HBO subscriptions in the U.S., far surpassing resellers like Apple and Google. Operators of smaller services have also told Variety in the past that Channels has become a major part of their business.Roku isn’t the only one taking a cue from Amazon: Bloomberg reported last month that Apple is looking to resell video subscriptions via its TV app, which is available on Apple TV and mobile devices. However, Apple’s subscription marketplace reportedly won’t launch before 2019, whereas Roku is looking to debut its service soon.Roku’s business model has long been about growing its audience with affordable streaming devices as well as partnerships with TV manufacturers, and then monetizing that audience through ads and services. The company does have some revenue share agreements with paid streaming services in place, but its biggest revenue contributor has been advertising. Revenue from ads and services surpassed Roku’s hardware revenue for the first time in the company’s history in Q1 of this year.One of the ways the company has grown its ad revenue has been the Roku channel, a free, ad-supported service that aggregates catalog titles from major Hollywood studios and other online content providers. In April, Roku added news from ABC, Cheddar, and others to the Roku Channel, which has since become one of the 10 most popular channels on the company’s devices. At this point, it’s unclear whether paid subscription services would also be directly integrated into the Roku Channel, or launch within a separate channel. Popular on Variety ×Actors Reveal Their Favorite Disney PrincessesSeveral actors, like Daisy Ridley, Awkwafina, Jeff Goldblum and Gina Rodriguez, reveal their favorite Disney princesses. Rapunzel, Mulan, Ariel,Tiana, Sleeping Beauty and Jasmine all got some love from the Disney stars.More VideosVolume 0%Press shift question mark to access a list of keyboard shortcutsKeyboard Shortcutsplay/pauseincrease volumedecrease volumeseek forwardsseek backwardstoggle captionstoggle fullscreenmute/unmuteseek to %SPACE↑↓→←cfm0-9Next UpJennifer Lopez Shares How She Became a Mogul04:350.5x1x1.25×1.5x2xLive00:0002:1502:15 read more
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Explore further (PhysOrg.com) — Scientists of many varied backgrounds have been hard at work in recent years trying to figure out a way to control the intricate processes that go on in cells so as to allow them to manipulate them to do their bidding. Much of that work has involved trying to code the genes at the outset. Now a joint team of American and Swiss researchers, working out of ETH Zurich, has taken a completely different approach. As they describe in their paper published in Nature Biotechnology, they have figured out a way to create a feedback loop between a computer and yeast cells (Saccharomyces cerevisiae), to control the production of proteins. Researchers could use plant’s light switch to control cells © 2011 PhysOrg.com Citation: Biochemists create computer controlled feedback loop with yeast (2011, November 8) retrieved 18 August 2019 from https://phys.org/news/2011-11-biochemists-feedback-loop-yeast.html Their discovery rests on the fact that yeast cells have a molecule in them called phytochrome that serves as a sort of switch, causing changes within the genetic structure that turns on a protein producing process, when a red light is shined on it. Interestingly, a darker red light causes the opposite effect; in its presence, the yeast cells go back to their original genetic structure and stop making the protein. Thus, using just two kinds of light the researchers can cause protein production to start or stop at their whim.What would be more interesting though is if the protein production process could be controlled through a feedback loop. To make this happen, the team introduced a so-called reporter molecule into the yeast cells that turn on (go fluorescent) when protein is being produced. Unfortunately, cell processes can’t be made to do their thing within certain constraints, such as say, turn on or off at specific time rates or intervals. To get around this problem, the team built a computer model to figure out how long light pulses should last in order for the yeast cells to produce the proteins when they wanted them too. They then set the whole process to working.What they constructed was a process that starts with a computer telling a red light when to shine, thus setting the yeast cells into action. The computer then monitors the reporter cells to note first when they come on, indicating proteins are being made. When just the right amount of time has elapsed, the computer then commands the red light to cease and the darker light to go on to cause the protein production to cease. The whole process can go on and on automatically because of the feedback loop, with a constant amount of proteins being produced all the while. And that’s the beauty of the whole thing, because if researchers can control yeast cells in such a manner, other applications quickly spring to mind, such as making drugs or creating biofuels. Though it may take time, this new process could very well revolutionize the way biological processes are manipulated. More information: In silico feedback for in vivo regulation of a gene expression circuit, Nature Biotechnology (2011) doi:10.1038/nbt.2018AbstractWe show that difficulties in regulating cellular behavior with synthetic biological circuits may be circumvented using in silico feedback control. By tracking a circuit’s output in Saccharomyces cerevisiae in real time, we precisely control its behavior using an in silico feedback algorithm to compute regulatory inputs implemented through a genetically encoded light-responsive module. Moving control functions outside the cell should enable more sophisticated manipulation of cellular processes whenever real-time measurements of cellular variables are possible. Sacharomyces cerevisiae cells in DIC microscopy. Credit: Wikipedia. read more
Age-Related Macular Degeneration (AMD) Market Get comprehensive research providing detailed regional analysis and growth outlook of the Global Age-Related Macular Degeneration (AMD) Market in the latest research report added by Big Market Research.Global Age-Related Macular Degeneration (AMD) Market is visual symptoms associated with dry age-related macular degeneration (AMD) is important for raising awareness of the condition and educating patients. a surge in the prevalence of eyerelated disorders and a rise in the global geriatric population boost the agerelated macular degeneration market. However, increase in the use of offlabel drugs and availability of offlabel therapies impedes the growth of the market.Request for a sample copy of this report @ https://www.bigmarketresearch.com/request-sample/3237744?utm_source=SHASHI-HTNThe report is an exhaustive analysis of this market across the world. 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These insights help in understanding the global trends in the Age-Related Macular Degeneration (AMD) industry and form strategies to be implemented in the future.The market across various regions is analyzed in the report, including North America, Europe, Asia-Pacific, and LAMEA. The report manifests the growth trends and future opportunities in every region. Additionally, the research provides a list of leading market players active in the Age-Related Macular Degeneration (AMD) industry.Avail the Discount on this Report @ https://www.bigmarketresearch.com/request-for-discount/3237744?utm_source=SHASHI-HTNThe key players explored in the industry include: Acucela, Alimera Sciences, Bayer Ag., F. Hoffmann-La Roche Ltd, Glaxosmithkline Plc, Neurotech PharmaceuticalsThe study clearly reveals that the Age-Related Macular Degeneration (AMD) industry has attained remarkable growth since 2024. This research report is prepared based on an in-depth analysis of the market by experts. As a final point, stakeholders, investors, product managers, marketing executives, and other professionals seeking unbiased data on supply, demand, and future forecasts would find the report valuable.Table of Contents Chapter 1 Executive SummaryChapter 2 Abbreviation and AcronymsChapter 3 Preface3.1 Research Scope3.2 Research Methodology3.2.1 Primary Sources3.2.2 Secondary Sources3.2.3 AssumptionsChapter 4 Market Landscape4.1 Market Overview4.2 Classification/Types4.3 Application/End UsersChapter 5 Market Trend Analysis5.1 Introduction5.2 Drivers5.3 Restraints5.4 Opportunities5.5 ThreatsChapter 6 Industry Chain Analysis6.1 Upstream/Suppliers Analysis6.2 Age-Related Macular Degeneration (AMD) Analysis6.2.1 Technology Analysis6.2.2 Cost Analysis6.2.3 Market Channel Analysis6.3 Downstream Buyers/End UsersReport Summary @ https://www.bigmarketresearch.com/report/3237744/global-age-related-macular-degeneration-amd-market-report-2019?utm_source=SHASHIAbout Us:Big Market Research has a range of research reports from various publishers across the world. Our database of reports of various market categories and sub-categories would help to find the exact report you may be looking for.We are instrumental in providing quantitative and qualitative insights on your area of interest by bringing reports from various publishers at one place to save your time and money. A lot of organizations across the world are gaining profits and great benefits from information gained through reports sourced by us.Contact us: Mr. Abhishek Paliwal5933 NE Win Sivers Drive, #205, Portland,OR 97220 United StatesDirect: +1-971-202-1575Toll Free: +1-800-910-6452Email firstname.lastname@example.org read more
News | Pediatric Imaging | August 14, 2019 Ultrasound Guidance Improves First-attempt Success in IV Access in Children August 14, 2019 – Children’s veins read more Related Content June 11, 2014 — Many people develop depression in the latest stages of life, but until now doctors had no idea that it could point to a build up of a naturally occurring protein in the brain called beta-amyloid, a hallmark of Alzheimer’s disease. In fact, late-life depression could become a major risk factor for developing Alzheimer’s faster than others, according to research unveiled at the Society of Nuclear Medicine and Molecular Imaging’s 2014 Annual Meeting (SNMMI).Alzheimer’s disease is a currently incurable neurodegenerative disease with marked protein aggregates including beta-amyloid and tau. The disease begins developing years before noticeable cognitive decline and memory loss. Depression has been proven to have its own neurodegenerative effects on the brain, but here researchers have found an undeniable connection between beta-amyloid in depressed elderly patients with cognitive deficits and advancement to Alzheimer’s disease. They were able to prove this using molecular imaging data from a global dementia imaging database.“Our results clearly indicate that mild cognitively impaired subjects with depressive symptoms suffer from elevated amyloid-levels when compared with non-depressed individuals,” said the study’s principal scientist Axel Rominger, M.D., from the department of nuclear medicine at the University of Munich in Germany. “The combination of elevated amyloid-levels and coexisting depressive symptoms constitute a patient population with a high risk for faster progression to Alzheimer’s disease.”The clinical study involved 371 patients with mild cognitive impairment who underwent PET imaging with the radiotracer F-18 florbetapir and magnetic resonance imaging (MRI) chosen retrospectively from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database, which includes data from at least 55 research centers across the United States and Canada now readily available to more than 2,500 researchers worldwide. Results showed that mild cognitive impaired patients with depressive symptoms had higher amyloid deposition than non-depressed controls as indicated by the binding of the radiotracer to amyloid particularly in the frontal cortex and the anterior and posterior cingulate gyrus of the brain, both involved in mood disorders such as depression.“Therapeutic options for Alzheimer’s disease are still limited and therefore the identification and understanding of contributing risk factors that influence the disease are crucial in ongoing research as they offer the possibilities for future medical intervention,” said co-author and fellow researcher Matthias Brendel. Additionally, knowing the risk could help patients make necessary lifestyle changes and prepare their families.For more information: www.snmmi.org FacebookTwitterLinkedInPrint分享 Image courtesy of UTHealth McGovern Medical School News | Radiation Therapy | August 15, 2019 First Patient Enrolled in World’s Largest Brain Cancer Clinical Trial Henry Ford Cancer Institute is first-in-the-world to enroll a glioblastoma patient in the GBM AGILE Trial (Adaptive… read more Images of regions of interest (colored lines) in the white matter skeleton representation. Data from left and right anterior thalamic radiation (ATR) were averaged. Image courtesy of C. Bouziane et al. Technology | Neuro Imaging | August 07, 2019 Synaptive Medical Launches Modus Plan With Automated Tractography Segmentation Synaptive Medical announced the U.S. launch and availability of Modus Plan featuring BrightMatter AutoSeg. This release… read more News | PET-CT | August 15, 2019 United Imaging Announces First U.S. Clinical Installation of uExplorer Total-body PET/CT United Imaging announced that its uExplorer total-body positron emission tomography/computed tomography (PET/CT) system… read more News | Stroke | August 16, 2019 Mobile Stroke Unit Gets Patients Quicker Treatment Than Traditional Ambulance Every second counts for stroke patients, as studies show they can lose up to 27 million brain cells per minute…. read more News | Neuro Imaging | August 16, 2019 ADHD Medication May Affect Brain Development in Children A drug used to treat attention-deficit/hyperactivity disorder (ADHD) appears to affect development of the brain’s… read more News | Brachytherapy Systems | August 14, 2019 Efficacy of Isoray’s Cesium Blu Showcased in Recent Studies August 14, 2019 — Isoray announced a trio of studies recently reported at scientific meetings and published in medica read more Feature | June 11, 2014 Depression in the Elderly Linked to Alzheimer’s Risk Molecular imaging study suggests late-life depression and beta-amyloid plaque in the brain could tip-off hastened development of the deadly dementia Image courtesy of Imago Systems News | Mammography | August 14, 2019 Imago Systems Announces Collaboration With Mayo Clinic for Breast Imaging Image visualization company Imago Systems announced it has signed a know-how license with Mayo Clinic. The multi-year… read more News | Artificial Intelligence | August 13, 2019 Artificial Intelligence Could Yield More Accurate Breast Cancer Diagnoses University of California Los Angeles (UCLA) researchers have developed an artificial intelligence (AI) system that… read more News | Cardiovascular Ultrasound | August 07, 2019 Contrast Use in First Transthoracic Echocardiogram for Heart Failure Reduces Repeat Testing Heart failure is the fourth most common cause for all admission to U.S. hospitals, and it is the most common reason for… read more read more